INNOVATIVE CONTROLLED OVARIAN HYPERSTIMULATION PROTOCOL FOR POLYCYSTIC OVARY SYNDROME PRODUCES HIGHER QUALITY OOCYTES, THE HIGHEST ACCUMULATIVE PREGNANCY RATE AT ONE CYCLE AND NO OVARIAN HYPER STIMULATION SYNDROME

In this study, we propose a new controlled ovarian hyperstimulation (COH) protocol for polycystic ovary syndrome(PCOS) that doesn’t cause hyper stimulation syndrome (OHSS) while maintaining egg quality. We also compare the conventional GnRH antagonist PCOS with COH at our hospital, and show is more secure than protocol. Eighty-seven patients of were treated in 38 49 patients. The was based on FSH / HMG injection started 3rd day menstruation. agonist used as Triger. difference from Letrozole when E2 value became 4000 pg/ml during stimulation. addition, after collection, 2 tablets each Cabergoline 1 tablet are administered 5 consecutive days. All embryos cryopreserved, then freeze-thaw embryo transfer performed. primary endpoint cumulative pregnancy rate (per collection), secondary endpoints clinical rate, number freezes, cryopreservation OHSS severity, Days between oocyte collection withdrawal hemorrhage. had higher per Furthermore, protocol, frozen significantly days hemorrhage lower.TableClinical outcome PCOSNew COHConventional antagonistNumber patients4938Cycles5144Average cryopreservations4.67 (A)3.36 (B)OHSS17%(9/51)(mild)50%(22/44)(mild〜severe)Days hemorrhage5.2 (A')24.97 (B')Cumulative (at one cycle)70.0%(35/50)55.8%(24/43)Cumulative miscarriage rate(at cycle)17.1%(6/35)37.5%(9/24)A-B , A'-B' : P<0.05(T-test） Open table tab A-B This has accumulative there no occurrence moderate-severe it very promising even though cases reported still low.